Molecular Mechanisms of Environmental Enrichment: Impairments in Akt/GSK3β, Neurotrophin-3 and CREB Signaling

Experience of mice in a complex environment enhances neurogenesis and synaptic plasticity in the hippocampus of wild type and transgenic mice harboring familial Alzheimer's disease (FAD)-linked APPswe/PS1ΔE9. In FAD mice, this experience also reduces levels of tau hyperphosphorylation and oligo...

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Detalhes bibliográficos
Main Authors: Hu, Yuan-Shih, Long, Nancy, Pigino, Gustavo, Brady, Scott T., Lazarov, Orly
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3660250/
https://ncbi.nlm.nih.gov/pubmed/23700479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0064460
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