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Coordinated host responses during pyroptosis: caspase-1-dependent lysosome exocytosis and inflammatory cytokine maturation

Activation of caspase-1 leads to pyroptosis, a program of cell death characterized by cell lysis and inflammatory cytokine release. Caspase-1 activation triggered by multiple NLRs (NLRC4, NLRP1b, or NLRP3) leads to loss of lysosomes via their fusion with the cell surface, or lysosome exocytosis. Act...

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Hlavní autoři: Bergsbaken, Tessa, Fink, Susan L., den Hartigh, Andreas B., Loomis, Wendy P., Cookson, Brad T.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3660150/
https://ncbi.nlm.nih.gov/pubmed/21804020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1100477
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