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Anthrax lethal toxin and Salmonella elicit the common cell death pathway of caspase-1-dependent pyroptosis via distinct mechanisms

Caspase-1 cleaves the inactive IL-1β and IL-18 precursors into active inflammatory cytokines. In Salmonella-infected macrophages, caspase-1 also mediates a pathway of proinflammatory programmed cell death termed “pyroptosis.” We demonstrate active caspase-1 diffusely distributed in the cytoplasm and...

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Autors principals: Fink, Susan L., Bergsbaken, Tessa, Cookson, Brad T.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2393760/
https://ncbi.nlm.nih.gov/pubmed/18337499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0707370105
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