Targeting Bcl-2-IP3 Receptor Interaction to Reverse Bcl-2’s Inhibition of Apoptotic Calcium Signals

The antiapoptotic protein Bcl-2 inhibits Ca(2+) release from the endoplasmic reticulum (ER). One proposed mechanism involves an interaction of Bcl-2 with the inositol 1,4,5-trisphosphate receptor (IP3R) Ca(2+) channel localized with Bcl-2 on the ER. Here we document Bcl-2-IP3R interaction within cel...

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Autors principals: Rong, Yi-Ping, Aromolaran, Ademuyiwa S., Bultynck, Geert, Zhong, Fei, Li, Xiang, McColl, Karen, Matsuyama, Shigemi, Herlitze, Stephan, Roderick, H. Llewelyn, Bootman, Martin D., Mignery, Gregory A., Parys, Jan B., De Smedt, Humbert, Distelhorst, Clark W.
Format: Artigo
Idioma:Inglês
Publicat: 2008
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3660092/
https://ncbi.nlm.nih.gov/pubmed/18657507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2008.06.014
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