The BH4 domain of Bcl-2 inhibits ER calcium release and apoptosis by binding the regulatory and coupling domain of the IP3 receptor

Although the presence of a BH4 domain distinguishes the antiapoptotic protein Bcl-2 from its proapoptotic relatives, little is known about its function. BH4 deletion converts Bcl-2 into a proapoptotic protein, whereas a TAT-BH4 fusion peptide inhibits apoptosis and improves survival in models of dis...

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Detalhes bibliográficos
Main Authors: Rong, Yi-Ping, Bultynck, Geert, Aromolaran, Ademuyiwa S., Zhong, Fei, Parys, Jan B., De Smedt, Humbert, Mignery, Gregory A., Roderick, H. Llewelyn, Bootman, Martin D., Distelhorst, Clark W.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2728114/
https://ncbi.nlm.nih.gov/pubmed/19706527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0907555106
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