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Transcriptional mutagenesis: causes and involvement in tumor development
The majority of normal cells in a human do not multiply continuously but are quiescent and devote most of their energy to gene transcription. When DNA damages in the transcribed strand of an active gene are bypassed by an RNA polymerase, they can miscode at the damaged site and produce mutant transc...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3659810/ https://ncbi.nlm.nih.gov/pubmed/21346784 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrc3006 |
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