Abasic sites and strand breaks in DNA cause transcriptional mutagenesis in Escherichia coli

DNA damage occurs continuously, and faithful replication and transcription are essential for maintaining cell viability. Cells in nature are not dividing and replicating DNA often; therefore it is important to consider the outcome of RNA polymerase (RNAP) encounters with DNA damage. Base damage in t...

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Bibliographic Details
Main Authors: Clauson, Cheryl L., Oestreich, Kenneth J., Austin, James W., Doetsch, Paul W.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2010
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2840506/
https://ncbi.nlm.nih.gov/pubmed/20142484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0913191107
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