Functional Impairment of Human Resident Cardiac Stem Cells by the Cardiotoxic Antineoplastic Agent Trastuzumab

Trastuzumab (TZM), a monoclonal antibody against the ERBB2 protein, increases survival in ERBB2-positive breast cancer patients. Its clinical use, however, is limited by cardiotoxicity. We sought to evaluate whether TZM cardiotoxicity involves inhibition of human adult cardiac-derived stem cells, in...

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Main Authors: Barth, Andreas S., Zhang, Yiqiang, Li, Taosheng, Smith, Rachel R., Chimenti, Isotta, Terrovitis, Ioannis, Davis, Darryl R., Kizana, Eddy, Ho, Alice S., O'Rourke, Brian, Wolff, Antonio C., Gerstenblith, Gary, Marbán, Eduardo
Formato: Artigo
Idioma:Inglês
Publicado: AlphaMed Press 2012
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Original Articles and Reviews
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3659699/
https://ncbi.nlm.nih.gov/pubmed/23197808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5966/sctm.2011-0016
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