Functional Impairment of Human Resident Cardiac Stem Cells by the Cardiotoxic Antineoplastic Agent Trastuzumab

Trastuzumab (TZM), a monoclonal antibody against the ERBB2 protein, increases survival in ERBB2-positive breast cancer patients. Its clinical use, however, is limited by cardiotoxicity. We sought to evaluate whether TZM cardiotoxicity involves inhibition of human adult cardiac-derived stem cells, in...

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Detaylı Bibliyografya
Asıl Yazarlar: Barth, Andreas S., Zhang, Yiqiang, Li, Taosheng, Smith, Rachel R., Chimenti, Isotta, Terrovitis, Ioannis, Davis, Darryl R., Kizana, Eddy, Ho, Alice S., O'Rourke, Brian, Wolff, Antonio C., Gerstenblith, Gary, Marbán, Eduardo
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: AlphaMed Press 2012
Konular:
Original Articles and Reviews
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3659699/
https://ncbi.nlm.nih.gov/pubmed/23197808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5966/sctm.2011-0016
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