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Energetically Unfavorable Amide Conformations for N6-Acetyllysine Side Chains in Refined Protein Structures
The reversible acetylation of lysine to form N6-acetyllysine in the regulation of protein function is a hallmark of epigenetics. Acetylation of the positively charged amino group of the lysine side chain generates a neutral N-alkylacetamide moiety that serves as a molecular “switch” for the modulati...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3659166/ https://ncbi.nlm.nih.gov/pubmed/23401043 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.24262 |
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