Ageing Fxr Deficient Mice Develop Increased Energy Expenditure, Improved Glucose Control and Liver Damage Resembling NASH

Nuclear receptor subfamily 1, group H, member 4 (Nr1h4, FXR) is a bile acid activated nuclear receptor mainly expressed in the liver, intestine, kidney and adrenal glands. Upon activation, the primary function is to suppress cholesterol 7 alpha-hydroxylase (Cyp7a1), the rate-limiting enzyme in the c...

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Detalhes bibliográficos
Main Authors: Bjursell, Mikael, Wedin, Marianne, Admyre, Therése, Hermansson, Majlis, Böttcher, Gerhard, Göransson, Melker, Lindén, Daniel, Bamberg, Krister, Oscarsson, Jan, Bohlooly-Y, Mohammad
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3659114/
https://ncbi.nlm.nih.gov/pubmed/23700488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0064721
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