Monoclonal Antibody Targeting of Fibroblast Growth Factor Receptor 1c Ameliorates Obesity and Glucose Intolerance via Central Mechanisms

We have generated a novel monoclonal antibody targeting human FGFR1c (R1c mAb) that caused profound body weight and body fat loss in diet-induced obese mice due to decreased food intake (with energy expenditure unaltered), in turn improving glucose control. R1c mAb also caused weight loss in leptin-...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Lelliott, Christopher J., Ahnmark, Andrea, Admyre, Therese, Ahlstedt, Ingela, Irving, Lorraine, Keyes, Feenagh, Patterson, Laurel, Mumphrey, Michael B., Bjursell, Mikael, Gorman, Tracy, Bohlooly-Y, Mohammad, Buchanan, Andrew, Harrison, Paula, Vaughan, Tristan, Berthoud, Hans-Rudolf, Lindén, Daniel
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4245083/
https://ncbi.nlm.nih.gov/pubmed/25427253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0112109
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