An antiapoptotic Bcl-2 family protein index predicts the response of leukaemic cells to the pan-Bcl-2 inhibitor S1

BACKGROUND: Bcl-2-like members have been found to be inherently overexpressed in many types of haematologic malignancies. The small-molecule S1 is a BH3 mimetic and a triple inhibitor of Bcl-2, Mcl-1 and Bcl-XL. METHODS: The lethal dose 50 (LD(50)) values of S1 in five leukaemic cell lines and 41 ne...

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Detalhes bibliográficos
Main Authors: Zhang, Z, Liu, Y, Song, T, Xue, Z, Shen, X, Liang, F, Zhao, Y, Li, Z, Sheng, H
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
Assuntos:
Molecular Diagnostics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3658527/
https://ncbi.nlm.nih.gov/pubmed/23558901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2013.152
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