Increasing Echinocandin Resistance in Candida glabrata: Clinical Failure Correlates With Presence of FKS Mutations and Elevated Minimum Inhibitory Concentrations

Background. Fluconazole (FLC) resistance is common in C. glabrata and echinocandins are often used as first-line therapy. Resistance to echinocandin therapy has been associated with FKS1 and FKS2 gene alterations. Methods. We reviewed records of all patients with C. glabrata bloodstream infection at...

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Main Authors:	Alexander, Barbara D., Johnson, Melissa D., Pfeiffer, Christopher D., Jiménez-Ortigosa, Cristina, Catania, Jelena, Booker, Rachel, Castanheira, Mariana, Messer, Shawn A., Perlin, David S., Pfaller, Michael A.
Format:	Artigo
Language:	Inglês
Published:	Oxford University Press 2013
Subjects:	Articles and Commentaries
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3658363/ https://ncbi.nlm.nih.gov/pubmed/23487382 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cid/cit136
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Increasing Echinocandin Resistance in Candida glabrata: Clinical Failure Correlates With Presence of FKS Mutations and Elevated Minimum Inhibitory Concentrations

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