Behavioral and Structural Responses to Chronic Cocaine Require a Feedforward Loop Involving ΔFosB and Calcium/Calmodulin-Dependent Protein Kinase II in the Nucleus Accumbens Shell

The transcription factor ΔFosB and the brain-enriched calcium/calmodulin-dependent protein kinase II (CaMKIIα) are induced in the nucleus accumbens (NAc) by chronic exposure to cocaine or other psychostimulant drugs of abuse, in which the two proteins mediate sensitized drug responses. Although ΔFos...

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Autors principals: Robison, Alfred J., Vialou, Vincent, Mazei-Robison, Michelle, Feng, Jian, Kourrich, Saïd, Collins, Miles, Wee, Sunmee, Koob, George, Turecki, Gustavo, Neve, Rachael, Thomas, Mark, Nestler, Eric J.
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2013
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3658178/
https://ncbi.nlm.nih.gov/pubmed/23467346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5192-12.2013
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