Relapse or eradication of cancer is predicted by peptide-MHC affinity

Cancers often relapse after adoptive therapy, even though specific T cells kill cells from the same cancer efficiently in vitro. We found that tumor eradication by T cells required high affinities of the targeted peptides for MHC class I. Affinities of at least 10 nM were required for relapse-free r...

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Hauptverfasser: Engels, Boris, Engelhard, Victor H., Sidney, John, Sette, Alessandro, Binder, David C., Liu, Rebecca B., Kranz, David M., Meredith, Stephen C., Rowley, Donald A., Schreiber, Hans
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3658176/
https://ncbi.nlm.nih.gov/pubmed/23597565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2013.03.018
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