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Efficacy of the β(2)-adrenergic receptor is determined by conformational equilibrium in the transmembrane region
Many drugs that target G-protein-coupled receptors (GPCRs) induce or inhibit their signal transduction with different strengths, which affect their therapeutic properties. However, the mechanism underlying the differences in the signalling levels is still not clear, although several structures of GP...
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| Main Authors: | , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Nature Pub. Group
2012
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3658005/ https://ncbi.nlm.nih.gov/pubmed/22948827 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms2046 |
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