Efficacy of the β(2)-adrenergic receptor is determined by conformational equilibrium in the transmembrane region

Many drugs that target G-protein-coupled receptors (GPCRs) induce or inhibit their signal transduction with different strengths, which affect their therapeutic properties. However, the mechanism underlying the differences in the signalling levels is still not clear, although several structures of GP...

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Hlavní autoři: Kofuku, Yutaka, Ueda, Takumi, Okude, Junya, Shiraishi, Yutaro, Kondo, Keita, Maeda, Masahiro, Tsujishita, Hideki, Shimada, Ichio
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Pub. Group 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3658005/
https://ncbi.nlm.nih.gov/pubmed/22948827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms2046
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