Efficacy of the β(2)-adrenergic receptor is determined by conformational equilibrium in the transmembrane region

Many drugs that target G-protein-coupled receptors (GPCRs) induce or inhibit their signal transduction with different strengths, which affect their therapeutic properties. However, the mechanism underlying the differences in the signalling levels is still not clear, although several structures of GP...

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Detaylı Bibliyografya
Asıl Yazarlar: Kofuku, Yutaka, Ueda, Takumi, Okude, Junya, Shiraishi, Yutaro, Kondo, Keita, Maeda, Masahiro, Tsujishita, Hideki, Shimada, Ichio
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Pub. Group 2012
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3658005/
https://ncbi.nlm.nih.gov/pubmed/22948827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms2046
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