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Efficacy of the β(2)-adrenergic receptor is determined by conformational equilibrium in the transmembrane region

Many drugs that target G-protein-coupled receptors (GPCRs) induce or inhibit their signal transduction with different strengths, which affect their therapeutic properties. However, the mechanism underlying the differences in the signalling levels is still not clear, although several structures of GP...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Kofuku, Yutaka, Ueda, Takumi, Okude, Junya, Shiraishi, Yutaro, Kondo, Keita, Maeda, Masahiro, Tsujishita, Hideki, Shimada, Ichio
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Pub. Group 2012
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3658005/
https://ncbi.nlm.nih.gov/pubmed/22948827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms2046
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