Activation of heme biosynthesis by a small molecule that is toxic to fermenting Staphylococcus aureus

Staphylococcus aureus is a significant infectious threat to global public health. Acquisition or synthesis of heme is required for S. aureus to capture energy through respiration, but an excess of this critical cofactor is toxic to bacteria. S. aureus employs the heme sensor system (HssRS) to overco...

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Bibliografiska uppgifter
Huvudupphovsmän: Mike, Laura A., Dutter, Brendan F., Stauff, Devin L., Moore, Jessica L., Vitko, Nicholas P., Aranmolate, Olusegun, Kehl-Fie, Thomas E., Sullivan, Sarah, Reid, Paul R., DuBois, Jennifer L., Richardson, Anthony R., Caprioli, Richard M., Sulikowski, Gary A., Skaar, Eric P.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2013
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3657828/
https://ncbi.nlm.nih.gov/pubmed/23630262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1303674110
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