Clinically Relevant Hormone Treatments Fail to Induce Spinogenesis in Prefrontal Cortex of Aged Female Rhesus Monkeys

Preclinical animal models have provided strong evidence that estrogen (E) therapy (ET) enhances cognition and induces spinogenesis in neuronal circuits. However, clinical studies have been inconsistent, with some studies revealing adverse effects of ET, including an increased risk of dementia. In an...

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Autori principali: Ohm, Daniel T., Bloss, Erik B., Janssen, William G., Dietz, Karen C., Wadsworth, Shannon, Lou, Wendy, Gee, Nancy A., Lasley, Bill L., Rapp, Peter R., Morrison, John H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2012
Soggetti:
Brief Communications
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3657730/
https://ncbi.nlm.nih.gov/pubmed/22915112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1881-12.2012
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