Plasma membrane localization signals in the light chain of botulinum neurotoxin

Botulinum neurotoxin (BoNT) is a potent biological substance used to treat neuromuscular and pain disorders. Both BoNT type A and BoNT type E display high-affinity uptake into motor neurons and inhibit exocytosis through cleavage of the synaptosome-associated protein of 25 kDa (SNAP25). The therapeu...

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Autores principales: Fernández-Salas, Ester, Steward, Lance E., Ho, Helen, Garay, Patton E., Sun, Sarah W., Gilmore, Marcella A., Ordas, Joseph V., Wang, Joanne, Francis, Joseph, Aoki, K. Roger
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2004
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC365768/
https://ncbi.nlm.nih.gov/pubmed/14982988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0400229101
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