Glycosylation-independent targeting enhances enzyme delivery to lysosomes and decreases storage in mucopolysaccharidosis type VII mice

Enzyme-replacement therapy is an established means of treating lysosomal storage diseases. Infused therapeutic enzymes are targeted to lysosomes of affected cells by interactions with cell-surface receptors that recognize carbohydrate moieties, such as mannose and mannose 6-phosphate, on the enzymes...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	LeBowitz, Jonathan H., Grubb, Jeffrey H., Maga, John A., Schmiel, Deborah H., Vogler, Carole, Sly, William S.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2004
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC365748/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14976248/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0308728100
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