Reengineered salivary glands are stable endogenous bioreactors for systemic gene therapeutics

The use of critical-for-life organs (e.g., liver or lung) for systemic gene therapeutics can lead to serious safety concerns. To circumvent such issues, we have considered salivary glands (SGs) as an alternative gene therapeutics target tissue. Given the high secretory abilities of SGs, we hypothesi...

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Autori principali: Voutetakis, Antonis, Kok, Marc R., Zheng, Changyu, Bossis, Ioannis, Wang, Jianghua, Cotrim, Ana P., Marracino, Natanya, Goldsmith, Corinne M., Chiorini, John A., Loh, Y. Peng, Nieman, Lynnette K., Baum, Bruce J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2004
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC365743/
https://ncbi.nlm.nih.gov/pubmed/14978265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0400136101
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