Reengineered salivary glands are stable endogenous bioreactors for systemic gene therapeutics

The use of critical-for-life organs (e.g., liver or lung) for systemic gene therapeutics can lead to serious safety concerns. To circumvent such issues, we have considered salivary glands (SGs) as an alternative gene therapeutics target tissue. Given the high secretory abilities of SGs, we hypothesi...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Voutetakis, Antonis, Kok, Marc R., Zheng, Changyu, Bossis, Ioannis, Wang, Jianghua, Cotrim, Ana P., Marracino, Natanya, Goldsmith, Corinne M., Chiorini, John A., Loh, Y. Peng, Nieman, Lynnette K., Baum, Bruce J.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2004
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC365743/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14978265/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0400136101
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