Mutant p53 prolongs NF-κB activation and promotes chronic inflammation and inflammation-associated colorectal cancer

The tumor suppressor p53 is frequently mutated in human cancer. Common mutant p53 (mutp53) isoforms can actively promote cancer through gain-of-function (GOF) mechanisms. We report that mutp53 prolongs TNF-α-induced NF-κB activation in cultured cells and intestinal organoid cultures. Remarkably, whe...

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Bibliografische gegevens
Hoofdauteurs: Cooks, Tomer, Pateras, Ioannis S., Tarcic, Ohad, Solomon, Hilla, Schetter, Aaron J., Wilder, Sylvia, Lozano, Guillermina, Pikarsky, Eli, Forshew, Tim, Rozenfeld, Nitzan, Harpaz, Noam, Itzkowitz, Steven, Harris, Curtis C., Rotter, Varda, Gorgoulis, Vassilis G., Oren, Moshe
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2013
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3657134/
https://ncbi.nlm.nih.gov/pubmed/23680148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2013.03.022
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