Avidity of influenza-specific memory CD8(+) T-cell populations decays over time compromising antiviral immunity

Decline of cell-mediated immunity is often attributed to decaying T-cell numbers and their distribution in peripheral organs. This study examined the hypothesis that qualitative as well as quantitative changes contribute to the declining efficacy of CD8(+) T-cell memory. Using a model of influenza v...

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Dettagli Bibliografici
Autori principali: Humphreys, Ian R, Clement, Mathew, Marsden, Morgan, Ladell, Kristin, McLaren, James E, Smart, Kathryn, Hindley, James P, Bridgeman, Hayley M, van den Berg, Hugo A, Price, David A, Ager, Ann, Wooldridge, Linda, Godkin, Andrew, Gallimore, Awen M
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Publishing Ltd 2012
Soggetti:
Immunity to Infection
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3657127/
https://ncbi.nlm.nih.gov/pubmed/22965681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201242575
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