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A small molecular activator of cardiac hypertrophy uncovered in a chemical screen for modifiers of the calcineurin signaling pathway

The calcium, calmodulin-dependent phosphatase calcineurin, regulates growth and gene expression of striated muscles. The activity of calcineurin is modulated by a family of cofactors, referred to as modulatory calcineurin-interacting proteins (MCIPs). In the heart, the MCIP1 gene is activated by cal...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Bush, Erik, Fielitz, Jens, Melvin, Lawrence, Martinez-Arnold, Michael, McKinsey, Timothy A., Plichta, Ryan, Olson, Eric N.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2004
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC365712/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14976250/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0308723101
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