Sorafenib Hepatobiliary Disposition: Mechanisms of Hepatic Uptake and Disposition of Generated Metabolites

Sorafenib is an orally active tyrosine kinase inhibitor used in the treatment of renal and hepatocellular carcinoma. This study was designed to establish whether transport proteins are involved in the hepatic uptake of sorafenib and to determine the extent of biliary excretion of sorafenib and its m...

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Detalhes bibliográficos
Main Authors: Swift, Brandon, Nebot, Noelia, Lee, Jin Kyung, Han, Tianxiang, Proctor, William R., Thakker, Dhiren R., Lang, Dieter, Radtke, Martin, Gnoth, Mark J., Brouwer, Kim L. R.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3657095/
https://ncbi.nlm.nih.gov/pubmed/23482500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.112.048181
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