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Tissue damage in the amyloidoses: Transthyretin monomers and nonnative oligomers are the major cytotoxic species in tissue culture

The transthyretin (TTR) amyloidoses are human diseases in which the misfolded TTR protein aggregates in tissues with subsequent visceral, peripheral, and autonomic nerve dysfunction. Recent reports have stressed the importance of oligomeric intermediates as major cytotoxic species in various forms o...

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Autors principals: Reixach, Natàlia, Deechongkit, Songpon, Jiang, Xin, Kelly, Jeffery W., Buxbaum, Joel N.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2004
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC365703/
https://ncbi.nlm.nih.gov/pubmed/14981241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0400062101
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