Hypothalamic κ-Opioid Receptor Modulates the Orexigenic Effect of Ghrelin

The opioid system is well recognized as an important regulator of appetite and energy balance. We now hypothesized that the hypothalamic opioid system might modulate the orexigenic effect of ghrelin. Using pharmacological and gene silencing approaches, we demonstrate that ghrelin utilizes a hypothal...

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Autors principals: Romero-Picó, Amparo, Vázquez, Maria J, González-Touceda, David, Folgueira, Cintia, Skibicka, Karolina P, Alvarez-Crespo, Mayte, Van Gestel, Margriet A, Velásquez, Douglas A, Schwarzer, Christoph, Herzog, Herbert, López, Miguel, Adan, Roger A, Dickson, Suzanne L, Diéguez, Carlos, Nogueiras, Rubén
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2013
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3656373/
https://ncbi.nlm.nih.gov/pubmed/23348063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2013.28
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