Hypothalamic κ-Opioid Receptor Modulates the Orexigenic Effect of Ghrelin

The opioid system is well recognized as an important regulator of appetite and energy balance. We now hypothesized that the hypothalamic opioid system might modulate the orexigenic effect of ghrelin. Using pharmacological and gene silencing approaches, we demonstrate that ghrelin utilizes a hypothal...

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Detalhes bibliográficos
Main Authors: Romero-Picó, Amparo, Vázquez, Maria J, González-Touceda, David, Folgueira, Cintia, Skibicka, Karolina P, Alvarez-Crespo, Mayte, Van Gestel, Margriet A, Velásquez, Douglas A, Schwarzer, Christoph, Herzog, Herbert, López, Miguel, Adan, Roger A, Dickson, Suzanne L, Diéguez, Carlos, Nogueiras, Rubén
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3656373/
https://ncbi.nlm.nih.gov/pubmed/23348063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2013.28
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