Point Mutation in Luminal Loop 7 of Scap Protein Blocks Interaction with Loop 1 and Abolishes Movement to Golgi

Scap is a polytopic protein of the endoplasmic reticulum (ER) that controls cholesterol homeostasis by transporting sterol regulatory element-binding proteins (SREBPs) from the ER to the Golgi complex. Scap has eight transmembrane helices (TM) joined by four small hydrophilic loops and three large l...

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Bibliografiske detaljer
Main Authors: Zhang, Yinxin, Motamed, Massoud, Seemann, Joachim, Brown, Michael S., Goldstein, Joseph L.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2013
Fag:
Membrane Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3656263/
https://ncbi.nlm.nih.gov/pubmed/23564452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.469528
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