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β-Tubulin mutations that cause severe neuropathies disrupt axonal transport

Microtubules are fundamental to neuronal morphogenesis and function. Mutations in tubulin, the major constituent of microtubules, result in neuronal diseases. Here, we have analysed β-tubulin mutations that cause neuronal diseases and we have identified mutations that strongly inhibit axonal transpo...

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Hlavní autoři: Niwa, Shinsuke, Takahashi, Hironori, Hirokawa, Nobutaka
Médium: Artigo
Jazyk:Inglês
Vydáno: European Molecular Biology Organization 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3655465/
https://ncbi.nlm.nih.gov/pubmed/23503589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2013.59
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