Disease-associated mutations hyperactivate KIF1A motility and anterograde axonal transport of synaptic vesicle precursors

KIF1A is a kinesin family motor involved in the axonal transport of synaptic vesicle precursors (SVPs) along microtubules (MTs). In humans, more than 10 point mutations in KIF1A are associated with the motor neuron disease hereditary spastic paraplegia (SPG). However, not all of these mutations appe...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Chiba, Kyoko, Takahashi, Hironori, Chen, Min, Obinata, Hiroyuki, Arai, Shogo, Hashimoto, Koichi, Oda, Toshiyuki, McKenney, Richard J., Niwa, Shinsuke
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6744892/
https://ncbi.nlm.nih.gov/pubmed/31455732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1905690116
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