A Large-Scale Conformational Change Couples Membrane Recruitment to Cargo Binding in the AP2 Clathrin Adaptor Complex

The AP2 adaptor complex (α, β2, σ2, and μ2 subunits) crosslinks the endocytic clathrin scaffold to PtdIns4,5P(2)-containing membranes and transmembrane protein cargo. In the “locked” cytosolic form, AP2's binding sites for the two endocytic motifs, YxxΦ on the C-terminal domain of μ2 (C-μ2) and...

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Autors principals: Jackson, Lauren P., Kelly, Bernard T., McCoy, Airlie J., Gaffry, Thomas, James, Leo C., Collins, Brett M., Höning, Stefan, Evans, Philip R., Owen, David J.
Format: Artigo
Idioma:Inglês
Publicat: Cell Press 2010
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3655264/
https://ncbi.nlm.nih.gov/pubmed/20603002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2010.05.006
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