Clathrin promotes incorporation of cargo into coated pits by activation of the AP2 adaptor μ2 kinase

Endocytic cargo such as the transferrin receptor is incorporated into clathrin-coated pits by associating, via tyrosine-based motifs, with the AP2 complex. Cargo–AP2 interactions occur via the μ2 subunit of AP2, which needs to be phosphorylated for endocytosis to occur. The most likely role for μ2 p...

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Bibliografiske detaljer
Main Authors: Jackson, Antony P., Flett, Alexander, Smythe, Carl, Hufton, Lindsay, Wettey, Frank R., Smythe, Elizabeth
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2003
Fag:
Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2173513/
https://ncbi.nlm.nih.gov/pubmed/14581451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200304079
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