Clathrin promotes incorporation of cargo into coated pits by activation of the AP2 adaptor μ2 kinase

Endocytic cargo such as the transferrin receptor is incorporated into clathrin-coated pits by associating, via tyrosine-based motifs, with the AP2 complex. Cargo–AP2 interactions occur via the μ2 subunit of AP2, which needs to be phosphorylated for endocytosis to occur. The most likely role for μ2 p...

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Bibliographische Detailangaben
Hauptverfasser: Jackson, Antony P., Flett, Alexander, Smythe, Carl, Hufton, Lindsay, Wettey, Frank R., Smythe, Elizabeth
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2003
Schlagworte:
Report
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2173513/
https://ncbi.nlm.nih.gov/pubmed/14581451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200304079
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