A Peptide Antagonist of CD28 Signaling Attenuates Toxic Shock and Necrotizing Soft-Tissue Infection Induced by Streptococcus pyogenes

Staphylococcus aureus and group A Streptococcus pyogenes (GAS) express superantigen (SAg) exotoxin proteins capable of inducing lethal shock. To induce toxicity, SAgs must bind not only to the major histocompatibility complex II molecule of antigen-presenting cells and the variable β chain of the T-...

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Bibliografiske detaljer
Main Authors: Ramachandran, Girish, Tulapurkar, Mohan E., Harris, Kristina M., Arad, Gila, Shirvan, Anat, Shemesh, Ronen, DeTolla, Louis J., Benazzi, Cinzia, Opal, Steven M., Kaempfer, Raymond, Cross, Alan S.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2013
Fag:
Major Articles and Brief Reports
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3654752/
https://ncbi.nlm.nih.gov/pubmed/23493729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jit104
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