CD28 Homodimer Interface Mimetic Peptide Acts as a Preventive and Therapeutic Agent in Models of Severe Bacterial Sepsis and Gram-Negative Bacterial Peritonitis

Background. Severe gram-negative bacterial infections and sepsis are major causes of morbidity and mortality. Dysregulated, excessive proinflammatory cytokine expression contributes to the pathogenesis of sepsis. A CD28 mimetic peptide (AB103; previously known as p2TA) that attenuates CD28 signaling...

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Detalles Bibliográficos
Publicado en:J Infect Dis
Main Authors: Ramachandran, Girish, Kaempfer, Raymond, Chung, Chun-Shiang, Shirvan, Anat, Chahin, Abdullah B., Palardy, John E., Parejo, Nicolas A., Chen, Yaping, Whitford, Melissa, Arad, Gila, Hillman, Dalia, Shemesh, Ronen, Blackwelder, William, Ayala, Alfred, Cross, Alan S., Opal, Steven M.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2015
Assuntos:
Major Articles and Brief Reports
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4416127/
https://ncbi.nlm.nih.gov/pubmed/25305323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiu556
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