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Reduction of endogenous GRP78 levels improves secretion of a heterologous protein in CHO cells.

GRP78 is localized in the endoplasmic reticulum and associates with improperly folded or underglycosylated proteins. The role of GRP78 in secretion was studied in Chinese hamster ovary cells expressing a tissue plasminogen activator (tPA) variant which lacks potential N-linked glycosylation site seq...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Dorner, A J, Krane, M G, Kaufman, R J
Format: Artigo
Langue:Inglês
Publié: 1988
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC365475/
https://ncbi.nlm.nih.gov/pubmed/2460739
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