Structural and Functional Analysis of STING Sheds New Light on Cyclic di-GMP Mediated Immune Signaling Mechanism

STING is an essential signaling molecule for DNA and cyclic di-GMP (c-di-GMP)-mediated type I interferon (IFN) production via TANK-binding kinase 1 (TBK1) and Interferon regulatory factor 3 (IRF3) pathway. It contains an N-terminal transmembrane region and a cytosolic C-terminal domain (CTD). Here,...

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Autori principali: Ouyang, Songying, Song, Xianqiang, Wang, Yaya, Ru, Heng, Shaw, Neil, Jiang, Yan, Niu, Fengfeng, Zhu, Yanping, Qiu, Weicheng, Parvatiyar, Kislay, Li, Yang, Zhang, Rongguang, Cheng, Genhong, Liu, Zhi-Jie
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3654694/
https://ncbi.nlm.nih.gov/pubmed/22579474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2012.03.019
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