Identification of genetic variation that determines human trehalase activity and its association with type 2 diabetes

A prior linkage scan in Pima Indians identified a putative locus for type two diabetes (T2D) and body mass index (BMI) on chromosome 11q23-25. Association mapping across this region identified single nucleotide polymorphisms (SNPs) in the trehalase gene (TREH) that were associated with T2D. To asses...

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Hauptverfasser: Muller, Yunhua L., Hanson, Robert L., Knowler, William C., Fleming, Jamie, Goswami, Jayita, Huang, Ke, Traurig, Michael, Sutherland, Jeff, Wiedrich, Chris, Wiedrich, Kim, Mahkee, Darin, Ossowski, Vicky, Kobes, Sayuko, Bogardus, Clifton, Baier, Leslie J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer-Verlag 2013
Schlagworte:
Original Investigation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3654185/
https://ncbi.nlm.nih.gov/pubmed/23468175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00439-013-1278-3
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