Akt-mediated phosphorylation of Argonaute 2 down-regulates cleavage and up-regulates translational repression of microRNA targets

A high-throughput RNA interference (RNAi) screen targeting 542 genes of the human kinome was used to discover regulators of RNAi. Here we report that the proto-oncogene Akt-3/PKBγ (Akt3) phosphorylates Argonaute 2 (Ago2) at Ser387 which down-regulates cleavage and up-regulates translational repressi...

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Detalhes bibliográficos
Main Authors: Horman, Shane R., Janas, Maja M., Litterst, Claudia, Wang, Bingbing, MacRae, Ian J., Sever, Mary J., Morrissey, David V., Graves, Paul, Luo, Biao, Umesalma, Shaikamjad, Qi, Hank H., Miraglia, Loren J., Novina, Carl D., Orth, Anthony P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3654076/
https://ncbi.nlm.nih.gov/pubmed/23603119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2013.03.015
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