Akt-mediated phosphorylation of Argonaute 2 down-regulates cleavage and up-regulates translational repression of microRNA targets

A high-throughput RNA interference (RNAi) screen targeting 542 genes of the human kinome was used to discover regulators of RNAi. Here we report that the proto-oncogene Akt-3/PKBγ (Akt3) phosphorylates Argonaute 2 (Ago2) at Ser387 which down-regulates cleavage and up-regulates translational repressi...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Horman, Shane R., Janas, Maja M., Litterst, Claudia, Wang, Bingbing, MacRae, Ian J., Sever, Mary J., Morrissey, David V., Graves, Paul, Luo, Biao, Umesalma, Shaikamjad, Qi, Hank H., Miraglia, Loren J., Novina, Carl D., Orth, Anthony P.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2013
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3654076/
https://ncbi.nlm.nih.gov/pubmed/23603119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2013.03.015
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