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Cellular DNA rearrangements and early developmental arrest caused by DNA insertion in transgenic mouse embryos.

Insertional mutagenesis was investigated in a transgenic mouse strain (HUGH/4) derived from a fertilized egg injected with plasmid DNA containing the human growth hormone gene. Lethality occurred in homozygous embryos and was traced to the egg cylinder stage on days 4 to 5 of gestation, shortly afte...

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Detalhes bibliográficos
Main Authors: Covarrubias, L, Nishida, Y, Terao, M, D'Eustachio, P, Mintz, B
Formato: Artigo
Idioma:Inglês
Publicado em: 1987
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC365348/
https://ncbi.nlm.nih.gov/pubmed/3037353
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