Cellular DNA rearrangements and early developmental arrest caused by DNA insertion in transgenic mouse embryos.

Insertional mutagenesis was investigated in a transgenic mouse strain (HUGH/4) derived from a fertilized egg injected with plasmid DNA containing the human growth hormone gene. Lethality occurred in homozygous embryos and was traced to the egg cylinder stage on days 4 to 5 of gestation, shortly afte...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Covarrubias, L, Nishida, Y, Terao, M, D'Eustachio, P, Mintz, B
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 1987
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC365348/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3037353/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.7.6.2243-2247.1987
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