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Both K63 and K48 ubiquitin linkages signal lysosomal degradation of the LDL receptor

Linkage-specific ubiquitination often leads to distinct cellular events. It has been difficult to establish definitively the requirement for a particular linkage in mammalian degradation pathways due to the inability to deplete endogenous ubiquitin while maintaining cell viability. The E3 ubiquitin...

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Bibliographische Detailangaben
Hauptverfasser: Zhang, Li, Xu, Ming, Scotti, Elena, Chen, Zhijian J., Tontonoz, Peter
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Biochemistry and Molecular Biology 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3653405/
https://ncbi.nlm.nih.gov/pubmed/23419260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M035774
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