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Lipid-regulated degradation of HMG-CoA reductase and Insig-1 through distinct mechanisms in insect cells
In mammalian cells, levels of the integral membrane proteins 3-hydroxy-3-methylglutaryl-CoA reductase and Insig-1 are controlled by lipid-regulated endoplasmic reticulum-associated degradation (ERAD). The ERAD of reductase slows a rate-limiting step in cholesterol synthesis and results from sterol-i...
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| Autores principales: | , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
The American Society for Biochemistry and Molecular Biology
2013
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3653402/ https://ncbi.nlm.nih.gov/pubmed/23403031 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M033639 |
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