p53-dependent release of Alarmin HMGB1 is a central mediator of senescent phenotypes

Cellular senescence irreversibly arrests proliferation in response to potentially oncogenic stress. Senescent cells also secrete inflammatory cytokines such as IL-6, which promote age-associated inflammation and pathology. HMGB1 (high mobility group box 1) modulates gene expression in the nucleus, b...

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Detalhes bibliográficos
Main Authors: Davalos, Albert R., Kawahara, Misako, Malhotra, Gautam K., Schaum, Nicholas, Huang, Jiahao, Ved, Urvi, Beausejour, Christian M., Coppe, Jean-Philippe, Rodier, Francis, Campisi, Judith
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2013
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3653366/
https://ncbi.nlm.nih.gov/pubmed/23649808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201206006
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